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Tetrahydrocannabutol(THCB) is an extremely rare cannabinoid that can only be found in two strains originating from Italy and Cicily(FM2, CIN-RO)at 1-5% concentrations within the plant. It has an amethyst purple color and is a crystal solid at room temperature. There is no information about the vaporization point, but it is assumed to be between 350*F and 400*F.
What is the Potency/Strength of THCB compared to THC?
Chemistry data shows that THCB is almost 2x stronger than THC at CB1 receptors, which translates to a higher cannabinoid-like activity. It also shows that the activity in question is somewhat similar to THCV, which explains why the resulting effects are a combination of the mood elevating/nootropic factors of THCV, with the intoxicating/relaxing factors of THC.
What Are the Effects of THCB in relation to THC?
THCB tends to have a strong relaxing effect on the body with a mood-elevating effect. It has nearly identical cannabinoid effects to THC. Many individuals have noticed an antidepressant effect with THCB that is unique among the cannabinoids. The pain-relieving properties may also be more desirable over THC, as the ratio between pain relief and intoxication is more efficient due to a more efficient binding value of THCB to the CB1 receptor group. The binding affinity of THCB at CB1 receptors is 15nM. This value means that it is more potent than THC, which has a binding affinity of 40nM. A lower number means the binding is more favorable/fits better. However, THCB does not seem to be more intense than THC; the two cannabinoids are likely identical at maximum intensity.
Potential Therapeutic Applications of THCB?
-Anxiolytic(relief of anxiety)
Interesting Scientific Discoveries On THCB?
It is of great interest that THCB is more active at CB1 receptors despite a shorter side chain profile. CB1 receptors are a primary reason for the psychoactive, analgesic, and physical properties that cannabinoids have on the human body. The CH3 side chain of the molecule was theorized to dictate the overall potency/psychoactivity of the cannabinoid. The more links, the more potent the compound. Anything higher than 8 links results in dramatically reduced potency. This concept has been a standard that pharmacology and drug discovery fields expect, in regards to natural or synthetic cannabinoids that use the chemical scaffold(shape) of THC.
THC has a side chain length of 5 links, but THCB only has 4 links. This contradicts the theorized pattern of potency increasing with length and adds a layer of complexity to what was considered a simple molecular relationship. THCC has 1 link and is not psychoactive. THCV has 3 links and is ⅓ the potency of THC. THCH has 6 links and is 5x the potency of THC. THCP has 7 links, and is 20x the potency of THC. Information such as this just goes to show the amount of data the scientific community is still accumulating in regards to cannabis and hemp.
HighNorth Cannabinoids currently offers a 2000mg THCB/HHC Dual Distillate Jar, with both cannabinoids separated so a custom mixture can be decided upon! Price: $89.99 per 2000mg Dual Jar.
Identification of THCB and CBDB in flower:
Binding affinity of THCB: